Consolidated statements of operations and comprehensive loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Income Statement [Abstract]
Revenue from collaborations	$ 4,359
Operating expenses:
Research and development	104,153	$ 79,890
General and administrative	28,527	17,944
Total operating expenses	132,680	97,834
Loss from operations	(128,321)	(97,834)
Interest and other (expense) income, net	132	(10,548)
Loss before income tax expense	(128,189)	(108,382)
Income tax expense	(143)	(161)
Net loss	(128,332)	(108,543)
Other comprehensive (loss) and income:
Gain (loss) on pension plans	749	(141)
(Loss) gain on available for sale investments	(109)	68
Comprehensive loss	$ (127,692)	$ (108,616)
Net loss per share, basic and diluted	$ (3.22)	$ (10.87)
Weighted average shares of common stock, basic and diluted	39,855,403	9,988,191