X0306 4 2020-03-12 0 0001437402 ARDELYX, INC. ARDX 0001799355 Cadoret-Manier Onaiza C/O ARDELYX, INC. 34175 ARDENWOOD BLVD, SUITE 200 FREMONT CA 94555 1 0 0 0 Stock Option (Right to Buy) 5.23 2020-03-12 4 A 0 65890 0.00 A 2030-03-12 Common Stock 65890 65890 D The option becomes exercisable as it vests and the shares subject to the option vest in 36 successive, equal monthly installments on each monthly anniversary of March 12, 2020, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date. /s/ Elizabeth Grammer, Attorney-in-fact for Onaiza Cadoret-Manier 2020-03-16