Significant Agreements - Additional Information (Details)				1 Months Ended									6 Months Ended	12 Months Ended
		Aug. 31, 2025 USD ($)	Oct. 30, 2024 USD ($)	Jan. 31, 2026 USD ($)	Dec. 31, 2025 USD ($) shares	Oct. 31, 2025 USD ($)	Sep. 30, 2025 USD ($)	Jun. 30, 2025 USD ($)	Mar. 31, 2025 USD ($)	Dec. 31, 2024 USD ($)	Nov. 30, 2024 USD ($)	Jul. 31, 2024 USD ($) Employee Vote	Dec. 31, 2024 USD ($)	Dec. 31, 2025 USD ($) shares	Dec. 31, 2026
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
General and administrative expense	[1]												$ 4,304,000	$ 20,421,000
Related party accrued expenses and other current liabilities					$ 4,969,000					$ 5,504,000			5,504,000	4,969,000
Research and development expense	[2]												31,234,000	93,121,000
JADE201
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Special development and regulatory milestones payment						$ 22,000,000
Fee for nomination of a development candidate						1,500,000
Further milestone payment						$ 2,500,000
Percentage of royalty reduction						30.00%
Terminated period						60 days
Milestone payment and recorded the payment as research and development									$ 1,500,000
JADE001
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Special development and regulatory milestones payment			$ 22,000,000
Fee for nomination of a development candidate			1,500,000
Further milestone payment			$ 2,500,000
Percentage of royalty reduction			30.00%
JADE101
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Further milestone payment							$ 2,500,000
Terminated period			60 days
Milestone payment and recorded the payment as research and development										1,500,000
Nonrefundable sublicensee fee		$ 300,000								$ 100,000
Subsequent Event | JADE201
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Non refundable reservation fee				$ 1,000,000
Maximum | JADE201
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Special development and regulatory milestones payment						$ 24,000,000
Maximum | JADE001
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Maximum sublicensing fees			$ 20,100,000
Paragon Option Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of employees in joint development committee | Employee												2
Number of votes per each employee | Vote												1
Option expiration period												30 days
Prior written notice period to terminate												30 days
General and administrative expense													1,000,000	300,000
Paragon Option Agreement | APRIL
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Related party accrued expenses and other current liabilities					0									0
Paragon Option Agreement | APRIL | Research and Development Expense
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Additional development costs incurred													18,900,000	4,600,000
Paragon Option Agreement | JADE201
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Related party accrued expenses and other current liabilities					0									0
Paragon Option Agreement | JADE201 | Research and Development Expense
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Additional development costs incurred													2,400,000	5,700,000
Paragon Option Agreement | JADE301
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Related party accrued expenses and other current liabilities					4,900,000									4,900,000
Research and development expense					$ 1,500,000
Paragon Option Agreement | JADE301 | Research and Development Expense
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Additional development costs incurred													$ 2,100,000	$ 8,200,000
Paragon Option Agreement | Paragon
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of employees in joint development committee | Employee												2
Paragon Option Agreement | Parade
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Common stock warrant issued | shares					804,519									804,519
Percentage of outstanding capital stock to grant warrants					1.00%									1.00%
Paragon Option Agreement | Parade | Forecast
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percentage of outstanding capital stock to grant warrants															1.00%
Paragon Option Agreement | Achievement of Certain Clinical Development Milestones | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments required to be paid												$ 12,000,000
Paragon Option Agreement | Achievement of Certain Regulatory Milestones | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential milestone payments required to be paid												$ 10,000,000
Cell Line License Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Prior written notice period to terminate												60 days
Non-refundable license fee											$ 200,000
Cell Line License Agreement | Research and Development Expense
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Nonrefundable sublicensee fee								$ 100,000

[1] Includes related party amount of $0.3 million for the year ended December 31, 2025 and $1.0 million for the period from June 18, 2024 (inception) to December 31, 2024 (see Note 13).

[2] Includes related party amount of $28.6 million for the year ended December 31, 2025 and $24.6 million for the period from June 18, 2024 (inception) to December 31, 2024 (see Note 13).