<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001798679</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001787306</issuerCik>
      <issuerName>Arcutis Biotherapeutics, Inc.</issuerName>
      <secFileNumber>001-39186</secFileNumber>
      <issuerAddress>
        <com:street1>3027 TOWNSGATE ROAD</com:street1>
        <com:street2>SUITE 300</com:street2>
        <com:city>WESTLAKE VILLAGE</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>91361</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>805-418-5006</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Matsuda Masaru</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill</name>
        <address>
          <com:street1>8890 Lyra Dr 5th Floor</com:street1>
          <com:city>Columbus</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>43240</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>36130</noOfUnitsSold>
      <aggregateMarketValue>583716.00</aggregateMarketValue>
      <noOfUnitsOutstanding>119905078</noOfUnitsOutstanding>
      <approxSaleDate>09/04/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/31/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Employer stock purchase plan</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1463</amountOfSecuritiesAcquired>
      <paymentDate>05/31/2023</paymentDate>
      <natureOfPayment>cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/31/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Employer stock purchase plan</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4000</amountOfSecuritiesAcquired>
      <paymentDate>05/31/2024</paymentDate>
      <natureOfPayment>cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>08/01/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>8562</amountOfSecuritiesAcquired>
      <paymentDate>08/01/2024</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/27/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1886</amountOfSecuritiesAcquired>
      <paymentDate>05/27/2023</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>common</securitiesClassTitle>
      <acquiredDate>05/27/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>3100</amountOfSecuritiesAcquired>
      <paymentDate>05/27/2024</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/01/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Rstricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>8766</amountOfSecuritiesAcquired>
      <paymentDate>05/01/2024</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/01/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4815</amountOfSecuritiesAcquired>
      <paymentDate>03/01/2024</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>11/18/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>3025</amountOfSecuritiesAcquired>
      <paymentDate>11/18/2023</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/01/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>513</amountOfSecuritiesAcquired>
      <paymentDate>03/01/2023</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Masaru Matsuda</name>
        <address>
          <com:street1>3027 Townsgate Rd Ste 300,</com:street1>
          <com:city>Westlake Village</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91361</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>08/04/2025</saleDate>
      <amountOfSecuritiesSold>6330</amountOfSecuritiesSold>
      <grossProceeds>90687.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>09/04/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>06/05/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>Masaru Matsuda</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
