X0306 4/A 2021-02-05 2021-02-08 0 0001490978 Schrodinger, Inc. SDGR 0001797829 Lebowitz Joel C/O SCHRODINGER, INC., 120 WEST 45TH STREET, 17TH FLOOR NEW YORK NY 10036 0 1 0 0 See Remarks Common Stock 2021-02-05 4 S 0 1115 99.8977 D 0 D This amendment is being filed solely to correct the transaction code from "P" to "S" for the sale of shares of common stock in connection with the transaction reported in the Form 4 filed by the reporting person on February 8, 2021. These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $99.60 to $100.20, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) of this Form 4/A. Executive Vice President and Chief Financial Officer /s/ Donald Shum, as attorney-in-fact for Joel Lebowitz 2021-02-18