X0306 4 2020-02-10 0 0001490978 Schrodinger, Inc. SDGR 0001797721 Brauner Shane C/O SCHRODINGER, INC., 120 WEST 45TH STREET, 17TH FLOOR NEW YORK NY 10036 0 1 0 0 See Remarks Stock Option (right to buy) 17.00 2020-02-10 4 A 0 53509 0.00 A 2030-02-04 Common Stock 53509 53509 D The option was granted on February 5, 2020. The commencement of vesting was contingent upon the closing of the Issuer's initial public offering, which occurred on February 10, 2020. The shares underlying the option are scheduled to vest with respect to 25% of the shares on February 5, 2021 and the remainder are scheduled to vest in equal monthly installments through February 5, 2024. Senior Vice President and Chief Information Officer /s/ Yvonne Tran, as attorney-in-fact for Shane Brauner 2020-02-10