X0206 3 2020-02-05 0 0001490978 Schrodinger, Inc. SDGR 0001797721 Brauner Shane C/O SCHRODINGER, INC., 120 WEST 45TH STREET, 17TH FLOOR NEW YORK NY 10036 0 1 0 0 See Remarks Common Stock 23410 D Stock Option (right to buy) 1.57 2024-05-19 Common Stock 3344 D Stock Option (right to buy) 1.57 2025-07-19 Common Stock 6688 D Stock Option (right to buy) 2.92 2027-06-01 Common Stock 11731 D Stock Option (right to buy) 4.34 2029-01-30 Common Stock 15022 D The option was granted on May 19, 2014 and is fully vested. The option was granted on July 20, 2015 and is fully vested. The option was granted on June 1, 2017. The shares underlying the option are scheduled to vest in equal yearly installments from January 1, 2017 through January 1, 2021. The option was granted on January 30, 2019. The shares underlying the option vested with respect to 25% of the shares on January 1, 2020 and the remainder are scheduled to vest in equal monthly installments through January 1, 2023. Senior Vice President and Chief Information Officer Exhibit Index: 24.1 Power of Attorney /s/ Yvonne Tran, as attorney-in-fact for Shane Brauner 2020-02-05