X0306 4 2022-04-14 0 0001782223 Pyxis Oncology, Inc. PYXS 0001796310 Yanchik Connealy Pamela C/O PYXIS ONCOLOGY, INC. 35 CAMBRIDGEPARK DRIVE CAMBRIDGE MA 02140 0 1 0 0 Chief Financial Officer Common Stock 2022-04-14 4 A 0 93493 0 A 341017 D Represents restricted stock units ("RSUs") that vest on April 13, 2023, subject to the Reporting Person's continued employment through the vesting date. The Compensation Committee also approved a grant to the Reporting Person, effective January 3, 2023, of an additional 43,493 RSUs that vest on April 13, 2023, subject to the Reporting Person's continued employment through the grant and vesting dates. /s/ Pamela Connealy 2022-04-15