X0306 4 2023-01-26 0 0001814114 Orchestra BioMed Holdings, Inc. OBIO 0001796310 Yanchik Connealy Pamela C/O ORCHESTRA BIOMED HOLDINGS, INC. 150 UNION SQUARE DRIVE NEW HOPE PA 18938 1 0 0 0 Common Stock, par value $0.0001 per share ("Common Stock") 2023-01-26 4 A 0 3488 A 3488 D Nonstatutory Stock Option (Right to Buy) 7.66 2023-01-26 4 A 0 18600 A 2030-06-29 Common Stock 18600 18600 D Nonstatutory Stock Option (Right to Buy) 10.00 2023-01-26 4 A 0 23250 A 2032-08-25 Common Stock 23250 23250 D These securities were issued on the closing date of the merger (the "Business Combination") contemplated by the Agreement and Plan of Merger, dated as of July 4, 2022, as amended by Amendment No. 1 thereto dated as of July 21, 2022 and Amendment No. 2 thereto dated as of November 21, 2022 (as amended, the "Merger Agreement"), by and among Orchestra BioMed Holdings, Inc. (f/k/a Health Sciences Acquisitions Corporation 2) ("HSAC2"), HSAC Olympus Merger Sub, Inc., a Delaware corporation and wholly owned subsidiary of HSAC2, and Orchestra BioMed, Inc., a Delaware corporation ("Legacy Orchestra"), in exchange for Legacy Orchestra securities. Received in the Business Combination in exchange for 7,500 shares of common stock of Legacy Orchestra ("Legacy Orchestra Common Stock"). The nonstatutory stock options ("NSOs") have vested and will vest in equal installments over a three-year period on a quarterly basis, starting with the last day of the last month of the first quarter after the grant date, subject to the Reporting Person's continuous service through such date. The grant date is June 30, 2020. Received in the Business Combination in exchange for a nonstatutory stock option to acquire 40,000 shares of Legacy Orchestra Common Stock for $3.56 per share. The NSOs vest over a three-year period as follows: (i) 33% of the underlying shares will vest on the first anniversary of the grant date and (ii) 67% of the underlying shares will vest in equal installments on a quarterly basis starting on the day of the month of the last month of the first quarter after the first anniversary of the grant date, that is the same day of the month as the grant date, subject to the Reporting Person's continuous service through such date. The grant date is August 18, 2022. Received in the Business Combination in exchange for a nonstatutory stock option to acquire 50,000 shares of Legacy Orchestra Common Stock for $4.65 per share. /s/ Matthew R. Schob, Attorney-in-Fact 2023-01-30