X0609 4 2026-06-23 0 0001814114 Orchestra BioMed Holdings, Inc. OBIO 0001796310 Connealy Pamela Ann false C/O ORCHESTRA BIOMED HOLDINGS, INC. 150 UNION SQUARE DRIVE NEW HOPE PA 18938 1 0 0 0 0 Common Stock, par value $0.0001 per share ("Common Stock") 2026-06-23 4 A 0 17327 0 A 66038 D Stock Option (Right to Buy) 4.04 2026-06-23 4 A 0 21277 0 A 2036-06-23 Common Stock 21277 21277 D Represents an award of restricted stock units ("RSUs") awarded to the Reporting Person on June 23, 2026 (the "Grant Date"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs will vest on the one year anniversary of the Grant Date, subject to the Reporting Person's continuous service through such date. The stock options will vest on the one year anniversary of the Grant Date, subject to the Reporting Person's continuous service through such date. /s/ Andrew Taylor, Attorney-in-Fact 2026-06-25