X0508 4 2025-03-31 false 0001782223 Pyxis Oncology, Inc. PYXS 0001796310 Connealy Pamela Ann C/O PYXIS ONCOLOGY, INC. 321 HARRISON AVENUE, 11TH FL. SUITE 1 BOSTON MA 02118 false true false false CFO & COO false Stock Option (Right to Buy) 0.98 2025-03-31 4 A false 414163 0.98 A 2035-03-31 Common Stock 414163 414163 D The shares subject to this option will vest over four years, with 25% vesting on the first anniversary of March 31, 2025 and the remainder vesting in 36 equal monthly installments thereafter subject to the reporting person's continued emmployment through the applicable vesting date. /s/ Pamela Connealy 2025-04-02