X0508 4 2024-11-26 false 0001782223 Pyxis Oncology, Inc. PYXS 0001796310 Connealy Pamela Ann C/O PYXIS ONCOLOGY, INC. 321 HARRISON AVENUE, 11TH FL. SUITE 1 BOSTON MA 02118 false true false false CFO & COO false Common Stock 2024-11-26 4 P false 5450 2 A 1115743 I By Trust Common Stock 2024-11-26 4 P false 83400 1.96 A 1199143 I By Spouse These shares are held directly by the Personal Def Ben Pln Trust, a revocable trust for which the Reporting Person and their spouse are the trustees. The price reported in column 4 is a weighted-average price.These shares were purchased in multiple transactions at prices ranging from $1.93 to $1.99, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein. /s/ Pamela Connealy 2024-11-27