SCHEDULE 13G/A 0001600420 XXXXXXXX LIVE 3 Common Stock, $0.0001 par value per share 09/30/2025 0001796280 ORIC Pharmaceuticals, Inc. 68622P109 240 E. Grand Ave, 2nd Floor South San Francisco CA 94080 The Column Group II, LP b DE 0 3540777 0 3540777 3540777 N 3.6 PN All such shares are held of record by TCG II LP (as defined in Item 2(a) below). TCG II GP LP (as defined in Item 2(a) below) is the general partner of TCG II LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson and David Goeddel are the managing partners of TCG II LP and may each be deemed to share voting, investment and dispositive power with respect to these securities. Based on 97,122,987 shares of Common Stock outstanding as reported by the Issuer in its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the "Commission") on August 12, 2025 (the "Form 10-Q"). The Column Group II GP, LP b DE 0 3540777 0 3540777 3540777 N 3.6 PN All such shares are held of record by TCG II LP. TCG II GP LP is the general partner of TCG II LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson and David Goeddel are the managing partners of TCG II LP and may each be deemed to share voting, investment and dispositive power with respect to these securities. Based on 97,122,987 shares of Common Stock outstanding as reported by the Issuer in its Form 10-Q. David V Goeddel b X1 86716 3540777 86716 3540777 3627493 N 3.7 IN 3,540,777 of such shares are held of record by TCG II LP. TCG II GP LP is the general partner of TCG II LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson and David Goeddel are the managing partners of TCG II LP and may each be deemed to share voting, investment and dispositive power with respect to these securities. Based on 97,122,987 shares of Common Stock outstanding as reported by the Issuer in its Form 10-Q. Peter Svennilson b V7 103341 3540777 103341 3540777 3644118 N 3.7 IN 3,540,777 of such shares are held of record by TCG II LP. TCG II GP LP is the general partner of TCG II LP and may be deemed to have voting, investment and dispositive power with respect to these securities. Peter Svennilson and David Goeddel are the managing partners of TCG II LP and may each be deemed to share voting, investment and dispositive power with respect to these securities. Based on 97,122,987 shares of Common Stock outstanding as reported by the Issuer in its Form 10-Q. ORIC Pharmaceuticals, Inc. 240 E. Grand Ave, 2nd Floor, South San Francisco, CA 94080 This Amendment No. 3 ("Amendment No. 3") amends and supplements the Schedule 13G initially filed with the Commission on February 16, 2021, as amended by Amendment No. 1 filed with the Commission on February 11, 2022 (collectively, the "Original Schedule 13G") and Amendment No. 2 filed with the Commission on November 14, 2024 and is being filed by The Column Group II, LP ("TCG II LP"), The Column Group II GP, LP ("TCG II GP LP" and together with TCG II LP, the "Reporting Entities") and Peter Svennilson ("Svennilson") and David Goeddel ("Goeddel" and together with Svennilson, the "Managing Individuals"). The Reporting Entities and the Managing Individuals collectively are referred to as the "Reporting Persons". The agreement among the Reporting Persons to file jointly in accordance with the provisions of Rule 13d-1(k)(1) under the Act was filed as Exhibit 1 to the Original Schedule 13G . Only those items that are hereby reported are amended; all other items reported in the Original Schedule 13G remain unchanged. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Capitalized terms not defined in this Amendment No. 3 have the meanings ascribed to them in the Original Schedule 13G. The address of the principal business office of each Reporting Person is c/o The Column Group, 1 Letterman Drive, Building D, Suite M-900, San Francisco, CA 94129. Each of TCG II LP and TCG II GP LP is a limited partnership organized under the laws of the State of Delaware. Goeddel is a citizen of the United States of America and Svennilson is a citizen of Sweden. Y See Row 9 of the cover page for each Reporting Person and the corresponding footnotes. Each of the Reporting Persons disclaims beneficial ownership as to such securities, except to the extent of his or its pecuniary interest therein. See Row 11 of the cover page for each Reporting Person and the corresponding footnotes. Each of the Reporting Persons disclaims beneficial ownership as to such securities, except to the extent of his or its pecuniary interest therein. See Row 5 of the cover page for each Reporting Person and the corresponding footnotes. Each of the Reporting Persons disclaims beneficial ownership as to such securities, except to the extent of his or its pecuniary interest therein. See Row 6 of the cover page for each Reporting Person and the corresponding footnotes. Each of the Reporting Persons disclaims beneficial ownership as to such securities, except to the extent of his or its pecuniary interest therein. See Row 7 of the cover page for each Reporting Person and the corresponding footnotes. Each of the Reporting Persons disclaims beneficial ownership as to such securities, except to the extent of his or its pecuniary interest therein. See Row 8 of the cover page for each Reporting Person and the corresponding footnotes. Each of the Reporting Persons disclaims beneficial ownership as to such securities, except to the extent of his or its pecuniary interest therein. N Y Y Y Y Y Y The Column Group II, LP /s/ James Evangelista, Attorney-in-Fact 11/14/2025 The Column Group II GP, LP /s/ James Evangelista, Attorney-in-Fact 11/14/2025 David V Goeddel /s/ James Evangelista, Attorney-in-Fact 11/14/2025 Peter Svennilson /s/ James Evangelista, Attorney-in-Fact 11/14/2025