SCHEDULE 13D

CUSIP No.

68622P109

Name of reporting person

SR One Capital Management, LLC

Check the appropriate box if a member of a Group (See Instructions)

(a)

(b)

SEC use only

Source of funds (See Instructions)

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

Checkbox not checked

Citizenship or place of organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 0.00
8	Shared Voting Power 4,615,384.00
9	Sole Dispositive Power 0.00
10	Shared Dispositive Power 4,615,384.00

Aggregate amount beneficially owned by each reporting person

4,615,384.00

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in Row (11)

4.75 %

Type of Reporting Person (See Instructions)

SCHEDULE 13D

CUSIP No.

68622P109

Name of reporting person

SR One Capital Opportunities Fund I, LP

Check the appropriate box if a member of a Group (See Instructions)

(a)

(b)

SEC use only

Source of funds (See Instructions)

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

Checkbox not checked

Citizenship or place of organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 0.00
8	Shared Voting Power 2,382,064.00
9	Sole Dispositive Power 0.00
10	Shared Dispositive Power 2,382,064.00

Aggregate amount beneficially owned by each reporting person

2,382,064.00

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in Row (11)

2.45 %

Type of Reporting Person (See Instructions)

SCHEDULE 13D

CUSIP No.

68622P109

Name of reporting person

SR One Capital Opportunities Partners I, LP

Check the appropriate box if a member of a Group (See Instructions)

(a)

(b)

SEC use only

Source of funds (See Instructions)

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

Checkbox not checked

Citizenship or place of organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 0.00
8	Shared Voting Power 2,382,064.00
9	Sole Dispositive Power 0.00
10	Shared Dispositive Power 2,382,064.00

Aggregate amount beneficially owned by each reporting person

2,382,064.00

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in Row (11)

2.45 %

Type of Reporting Person (See Instructions)

SCHEDULE 13D

CUSIP No.

68622P109

Name of reporting person

AMZL, LP

Check the appropriate box if a member of a Group (See Instructions)

(a)

(b)

SEC use only

Source of funds (See Instructions)

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

Checkbox not checked

Citizenship or place of organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 0.00
8	Shared Voting Power 1,538,461.00
9	Sole Dispositive Power 0.00
10	Shared Dispositive Power 1,538,461.00

Aggregate amount beneficially owned by each reporting person

1,538,461.00

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in Row (11)

1.60 %

Type of Reporting Person (See Instructions)

SCHEDULE 13D

CUSIP No.

68622P109

Name of reporting person

SR One Capital SMA Partners, LP

Check the appropriate box if a member of a Group (See Instructions)

(a)

(b)

SEC use only

Source of funds (See Instructions)

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

Checkbox not checked

Citizenship or place of organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 0.00
8	Shared Voting Power 1,538,461.00
9	Sole Dispositive Power 0.00
10	Shared Dispositive Power 1,538,461.00

Aggregate amount beneficially owned by each reporting person

1,538,461.00

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in Row (11)

1.60 %

Type of Reporting Person (See Instructions)

SCHEDULE 13D

CUSIP No.

68622P109

Name of reporting person

SR One Capital Fund II Aggregator, LP

Check the appropriate box if a member of a Group (See Instructions)

(a)

(b)

SEC use only

Source of funds (See Instructions)

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

Checkbox not checked

Citizenship or place of organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 0.00
8	Shared Voting Power 694,859.00
9	Sole Dispositive Power 0.00
10	Shared Dispositive Power 694,859.00

Aggregate amount beneficially owned by each reporting person

694,859.00

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in Row (11)

0.73 %

Type of Reporting Person (See Instructions)

SCHEDULE 13D

CUSIP No.

68622P109

Name of reporting person

SR One Capital Partners II, LP

Check the appropriate box if a member of a Group (See Instructions)

(a)

(b)

SEC use only

Source of funds (See Instructions)

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

Checkbox not checked

Citizenship or place of organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 0.00
8	Shared Voting Power 694,859.00
9	Sole Dispositive Power 0.00
10	Shared Dispositive Power 694,859.00

Aggregate amount beneficially owned by each reporting person

694,859.00

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in Row (11)

0.73 %

Type of Reporting Person (See Instructions)

SCHEDULE 13D

CUSIP No.

68622P109

Name of reporting person

Simeon George

Check the appropriate box if a member of a Group (See Instructions)

(a)

(b)

SEC use only

Source of funds (See Instructions)

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

Checkbox not checked

Citizenship or place of organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 0.00
8	Shared Voting Power 4,615,384.00
9	Sole Dispositive Power 0.00
10	Shared Dispositive Power 4,615,384.00

Aggregate amount beneficially owned by each reporting person

4,615,384.00

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in Row (11)

4.75 %

Type of Reporting Person (See Instructions)

SCHEDULE 13D

Item 1.

Security and Issuer

(a)

Title of Class of Securities:

Common Stock, $0.0001 par value per share

(b)

Name of Issuer:

ORIC Pharmaceuticals, Inc.

(c)

Address of Issuer's Principal Executive Offices:

240 E. Grand Ave, 2nd Floor, South San Francisco, CALIFORNIA , 94080.

Item 1 Comment:

This Amendment No. 1 ("Amendment No. 1") to Schedule 13D amends and supplements the statement on Schedule 13D originally filed on June 5, 2025 (the "Schedule 13D") relating to the Common Stock of the Issuer. Certain terms used but not defined in this Amendment No. 1 have the meanings assigned thereto in the Schedule 13D. Except as specifically provided herein, this Amendment No. 1 does not modify any of the information previously reported on the Schedule 13D.

Item 2.

Identity and Background

(a)

SR One Capital Management, LLC ("SR One Capital Management"); SR One Capital Opportunities Fund I, LP ("SR One Opportunities Fund I"); SR One Capital Opportunities Partners I, LP ("SR One Opportunities Partners I"); AMZL, LP ("AMZL"); SR One Capital SMA Partners, LP ("SMA Partners"); SR One Capital Fund II Aggregator, LP ("SR One Fund II Aggregator"); SR One Capital Partners II, LP ("SR One Partners II"); and Simeon George, M.D. ("Dr. George"). SR One Opportunities Fund I is directly controlled by its general partner, SR One Opportunities Partners I. AMZL is directly controlled by its general partner, SMA Partners. SR One Fund II Aggregator is directly controlled by its general partner, SR One Partners II. SR One Opportunities Partners I, SMA Partners and SR One Partners II are directly controlled by their general partners, SR One Capital Management, and Dr. George controls SR One Capital Management. Accordingly, each of SR One Capital Management and Dr. George may be deemed to have voting and dispositive power with respect to the SR One Opportunities Fund I Shares, SR One Fund II Aggregator Shares and the AMZL Shares (each as defined below). The persons named in this Item 2 are referred to individually as a "Reporting Person" and collectively as the "Reporting Persons." SR One Opportunities Fund I, AMZL and SR One Fund II Aggregator are referred to collectively as the "Funds."

(b)

The address of each Reporting Person for purposes of this filing is: c/o SR One Capital Management, LP, 985 Old Eagle School Road, Suite 511, Wayne, PA 19087.

(c)

The principal business of the Funds is to invest in and assist growth-oriented businesses. The principal business of SR One Opportunities Partners I is to act as the sole general partner of SR One Opportunities Fund I. The principal business of SMA Partners is to act as the sole general partner of AMZL. The principal business of SR One Partners II is to act as the sole general partner of SR One Fund II Aggregator. The principal business of SR One Capital Management is to act as the sole general partner of SR One Opportunities Partners I, SMA Partners, SR One Partners II and a number of affiliated partnerships with similar businesses. The principal business of Dr. George is to manage SR One Capital Management.

(d)

During the five years prior to the date hereof, none of the Reporting Persons has been convicted in a criminal proceeding or has been a party to a civil proceeding ending in a judgment, decree or final order enjoining future violations of, or prohibiting activities subject to, federal or state securities laws or finding any violation with respect to such laws.

(e)

(f)

SR One Opportunities Fund I, SR One Opportunities Partners I, AMZL, SMA Partners, SR One Fund II Aggregator and SR One Partners II are limited partnerships organized under the laws of the State of Delaware. SR One Capital Management is a limited liability company organized under the laws of the State of Delaware. Dr. George is a United States citizen.

Item 3.

Source and Amount of Funds or Other Consideration

Not applicable.

Item 4.

Purpose of Transaction

Not applicable.

Item 5.

Interest in Securities of the Issuer

(a)

The percentage of outstanding shares of Common Stock which may be deemed to be beneficially owned by each Reporting Person is set forth on Line 13 of such Reporting Person's cover sheet. Such percentage was calculated based on 97,223,442 shares of Common Stock, which includes the sum of (i) 97,122,987 shares of Common Stock reported by the Issuer to be outstanding as of August 5, 2025, on the Issuer's Form 10-Q filed with the Securities Exchange Commission on August 12, 2025 and (ii) the number of shares of Common Stock underlying Pre-Funded Warrants such Reporting Person is deemed to beneficially own (taking into account the Beneficial Ownership Limitation).

(b)

(i) sole power to vote or to direct the vote: See line 7 of cover sheets (ii) shared power to vote or to direct the vote: See line 8 of cover sheets (iii) sole power to dispose or to direct the disposition: See line 9 of cover sheets (iv) shared power to dispose or to direct the disposition: See line 10 of cover sheets

(c)

None of the Reporting Persons has effected any transaction in shares of Common Stock during the last 60 days.

(d)

No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, Common Stock beneficially owned by any of the Reporting Persons.

(e)

Each of the Reporting Persons has ceased to beneficially own five percent or more of the Issuer's Common Stock as of August 5, 2025. This Amendment No. 1 was triggered solely due to a change in the number of outstanding shares of Common Stock of the Issuer.

Item 6.

Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer

Not applicable.

Item 7.

Material to be Filed as Exhibits.

Exhibit 1 - Agreement regarding filing of joint Schedule 13D. Exhibit 2 - Power of Attorney regarding filings under the Securities Exchange Act of 1934, as amended.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

SR One Capital Management, LLC

Signature:	/s/ Sasha Keough
Name/Title:	Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member
Date:	08/14/2025

SR One Capital Opportunities Fund I, LP

Signature:	/s/ Sasha Keough
Name/Title:	Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member
Date:	08/14/2025

SR One Capital Opportunities Partners I, LP

Signature:	/s/ Sasha Keough
Name/Title:	Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member
Date:	08/14/2025

AMZL, LP

Signature:	/s/ Sasha Keough
Name/Title:	Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member
Date:	08/14/2025

SR One Capital SMA Partners, LP

Signature:	/s/ Sasha Keough
Name/Title:	Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member
Date:	08/14/2025

SR One Capital Fund II Aggregator, LP

Signature:	/s/ Sasha Keough
Name/Title:	Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member
Date:	08/14/2025

SR One Capital Partners II, LP

Signature:	/s/ Sasha Keough
Name/Title:	Sasha Keough, as attorney-in-fact for Simeon George, M.D., Managing Member
Date:	08/14/2025

Simeon George

Signature:	/s/ Sasha Keough
Name/Title:	Sasha Keough, as attorney-in-fact for Simoen George, M.D.
Date:	08/14/2025

Comments accompanying signature:

This Amendment No. 1 to Schedule 13D was executed by Sasha Keough on behalf of the individuals listed above pursuant to a Power of Attorney a copy of which is attached as Exhibit 2.