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Equity Incentive Plans and Stock-Based Compensation - Summary of Fair Value of Stock Options Estimated Using Black-Scholes Merton Option Pricing Model Assumptions (Details) - $ / shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Risk-free interest rate, minimum 0.60% 3.17% 1.40%
Risk-free interest rate, maximum 1.34% 5.59% 2.60%
Expected volatility, minimum 82.34% 88.01% 77.00%
Expected volatility, maximum 88.43% 95.11% 104.00%
Expected term (in years)     6 years 1 month 6 days
Expected dividend yield 0.00% 0.00% 0.00%
Minimum      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Stock price $ 13.36 $ 16.00 $ 1.60
Expected term (in years) 5 years 6 months 5 years 6 months  
Maximum      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Stock price $ 35.67 $ 35.92 $ 9.16
Expected term (in years) 6 years 29 days 6 years 29 days