144 0001793412 XXXXXXXX LIVE 0001806310 TAYSHA GENE THERAPIES, INC. 001-39536 3000 PEGASUS PARK DRIVE SUITE 1430 DALLAS TX 75247 214-612-0000 Kamran Alam Officer Common Stock Maxim Group LLC

300 Park Avenue, 16th Floor New York NY 10022

54491 156389.17 272794885 08/21/2025 Nasdaq Common Stock 08/21/2025 RSU Award Issuer N 54491 08/21/2025 Vested grant settled instock; consideration was Reporting Person's continued service as an employee ofthe Issuer. Y The Reporting Person is selling the securities set forth herein pursuant to a sell-to-cover arrangement for the purpose of satisfying income tax liabilities incurred upon vesting of restricted stock unit awards only. 08/21/2025 /s/ Kamran Alam