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Balance Sheet Components
12 Months Ended
Dec. 31, 2021
Balance Sheet Components [Abstract]  
Balance Sheet Components Balance Sheet Components
Selected balance sheet components consist of the following:
Cash and restricted cash
(In millions)December 31,
2021
December 31,
2020
December 31,
2019
Cash and cash equivalents$701.2 $844.4 $475.6 
Restricted cash, included in other current and non-current assets5.0 5.6 15.5 
Cash, cash equivalents and restricted cash$706.2 $850.0 $491.1 
Inventories
(In millions)December 31, 2021December 31, 2020
Raw materials$922.4 $958.4 
Work in process993.3 1,438.1 
Finished goods2,062.0 3,075.4 
Inventories$3,977.7 $5,471.9 
Inventory reserves totaled $519.0 million and $353.6 million at December 31, 2021 and 2020, respectively. Included as a component of cost of sales is expense related to the net realizable value of inventories of $474.9 million, $206.1 million and $399.2 million for the years ended December 31, 2021, 2020 and 2019, respectively.

Prepaid expenses and other current assets
(In millions)December 31, 2021December 31, 2020
Prepaid expenses$256.7 $267.8 
Available-for-sale fixed income securities38.2 39.1 
Fair value of financial instruments144.6 118.6 
Equity securities51.0 45.8 
Other current assets1,467.1 1,236.1 
Prepaid expenses and other current assets$1,957.6 $1,707.4 
Prepaid expenses consist primarily of prepaid rent, insurance and other individually insignificant items.
Property, plant and equipment, net
(In millions)December 31, 2021December 31, 2020
Machinery and equipment$3,054.0 $3,235.0 
Buildings and improvements1,808.5 1,954.8 
Construction in progress588.7 376.3 
Land and improvements137.9 155.8 
Gross property, plant and equipment5,589.1 5,721.9 
Accumulated depreciation2,400.5 2,262.0 
Property, plant and equipment, net$3,188.6 $3,459.9 
Capitalized software costs included in our consolidated balance sheets were $62.3 million and $70.9 million, net of accumulated depreciation, at December 31, 2021 and 2020, respectively. The Company periodically reviews the estimated useful lives of assets and makes adjustments when appropriate. Depreciation expense was approximately $509.5 million, $289.7 million and $256.1 million for the years ended December 31, 2021, 2020 and 2019, respectively.
Other assets
(In millions)December 31, 2021December 31, 2020
Equity method investments, clean energy investments$— $47.9 
Operating lease right-of-use assets290.8 323.6 
Other long-term assets879.9 676.0 
Other assets$1,170.7 $1,047.5 
Accounts payable
(In millions)December 31, 2021December 31, 2020
Trade accounts payable$1,056.1 $1,345.7 
Other payables601.3 558.5 
Accounts payable$1,657.4 $1,904.2 
Other current liabilities
(In millions)December 31, 2021December 31, 2020
Accrued sales allowances$1,362.1 $1,211.8 
Payroll and employee benefit liabilities 741.9 828.2 
Legal and professional accruals, including litigation accruals715.6 362.9 
Contingent consideration66.7 100.5 
Accrued restructuring233.5 149.2 
Equity method investments, clean energy investments10.9 47.5 
Accrued interest86.6 90.9 
Fair value of financial instruments61.0 103.6 
Operating lease liability86.7 92.9 
Other1,254.6 1,973.2 
Other current liabilities$4,619.6 $4,960.7 
Other long-term obligations
(In millions)December 31, 2021December 31, 2020
Employee benefit liabilities$876.4 $1,020.4 
Contingent consideration133.0 123.1 
Tax related items, including contingencies426.1 469.5 
Operating lease liability200.9 229.5 
Accrued restructuring64.3 134.8 
Other232.9 505.8 
Other long-term obligations$1,933.6 $2,483.1