Income Taxes - Summary of Net Deferred Income Tax Asset (Details) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Deferred tax assets:
Net operating losses	$ 85,763	$ 32,148
Capitalized research and development	57,378	65,606
Research and development credits	11,414	6,970
Equity-based compensation	9,562	21,035
Licenses	5,723	694
Accrued expenses	2,280	2,699
Basis difference on gain on 2022 sale of zipalertinib development subsidiary	1,638	1,700
Lease liability	709	590
Capitalized organizational and start-up expenses	83	101
Gross deferred tax assets	174,550	131,543
Valuation allowance	(173,785)	(130,939)	$ (87,371)
Net deferred tax asset	765	604
Deferred tax liability
ROU asset	695	457
Depreciation and amortization	70	147
Net deferred tax asset	$ 0	$ 0