License and Collaboration Agreements - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023	Dec. 31, 2023
License And Collaboration Agreements [Line Items]
Research and development costs	$ 36,259	$ 27,391	$ 66,905	$ 79,487
Harbour License Agreement [Member]
License And Collaboration Agreements [Line Items]
Upfront license fee				25,000
Harbour BioMed US Inc. [Member] | Harbour License Agreement [Member]
License And Collaboration Agreements [Line Items]
Upfront license fee			25,000
Harbour BioMed US Inc. [Member] | Maximum | Harbour License Agreement [Member] | Achievement Based [Member]
License And Collaboration Agreements [Line Items]
Aggregate amount of milestone payment			148,000
Harbour BioMed US Inc. [Member] | Maximum | Harbour License Agreement [Member] | Sales Based [Member]
License And Collaboration Agreements [Line Items]
Aggregate amount of milestone payment			$ 415,000
Pearl - Taiho
License And Collaboration Agreements [Line Items]
Percentage of profits from potential sales			50.00%
Research and development expense related to share of costs	5,200	5,500	$ 11,200	10,200
Accrued expenses and other current liabilities	2,400		2,400		$ 7,900
Research and development costs	$ 2,800	$ 2,100	$ 4,700	3,100
MIT | Collaboration Agreements [Member]
License And Collaboration Agreements [Line Items]
Research and development costs				$ 200