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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Operating activities:    
Net loss $ (67,485) $ (59,458) [1]
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 53 62
Equity-based compensation expense 24,375 14,910
Amortization/Accretion on Marketable Securities 3,098 233
License expense in exchange for subsidiary common stock 67 1,183
Acquired in-process research and development assets   6,447
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (3,269) (462)
Other assets   (18)
Accounts payable (4,835) 5,581
Accrued expenses and other current liabilities 4,563 1,750
Net cash used in operating activities (43,433) (29,772)
Investing activities:    
Purchases of property and equipment   (10)
Net cash acquired in Mica asset acquisition   1,450
Purchase of Marketable securities (525,813) (69,763)
Proceeds from sales and maturities of marketable securities 192,038 62,903
Net cash used in investing activities (333,775) (5,420)
Financing activities:    
Proceeds from issuance of common stock equivalents [2]   145,450
Proceeds from initial public offering 267,268  
Payment of issuance costs related to common stock equivalents [2]   (6,572)
Payment of deferred offering costs (2,688)  
Proceeds from issuance of noncontrolling interests 923 1,206
Proceeds from stock options exercise 3,281 56
Net cash provided by financing activities 268,784 140,140
Net decrease in cash and cash equivalents (108,424) 104,948
Cash and cash equivalents at beginning of year 168,198 63,250
Cash and cash equivalents at end of year 59,774 168,198
Noncash financing activities    
Deferred offering costs paid in the prior year $ 65  
Deferred offering costs in accounts payable and accrued expenses   $ 2,093
[1] The shares and per share amounts for the year ended December 31, 2020 were derived from the consolidated financial statements as of that date and were retroactively adjusted as a result of the Reorganization and Reverse Stock Split. See Note 3 to the consolidated financial statements for additional details.
[2] Changes in equity activities for the year ended December 31, 2020 were retroactively adjusted, including shares and per share amounts, as a result of the Reorganization and Reverse Stock Split. See Note 3 to the consolidated financial statements for additional details.