<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001789970</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001770069</issuerCik>
      <issuerName>MapLight Therapeutics, Inc.</issuerName>
      <secFileNumber>001-42914</secFileNumber>
      <issuerAddress>
        <com:street1>800 CHESAPEAKE DRIVE</com:street1>
        <com:city>REDWOOD CITY</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94063</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>650-839-4360</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Hanson Kristopher</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Jefferies LLC</name>
        <address>
          <com:street1>520 Madison Avenue, 4th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10022</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>16509</noOfUnitsSold>
      <aggregateMarketValue>199428.72</aggregateMarketValue>
      <noOfUnitsOutstanding>52850000</noOfUnitsOutstanding>
      <approxSaleDate>09/16/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/30/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Vested RSU</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Maplight Therapeutics, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>16509</amountOfSecuritiesAcquired>
      <paymentDate>07/30/2023</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kris Hanson</name>
        <address>
          <com:street1>800 Chesapeake Drive</com:street1>
          <com:city>Redwood City</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94063</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Maplight Therapeutics, Inc.</securitiesClassTitle>
      <saleDate>07/15/2026</saleDate>
      <amountOfSecuritiesSold>7260</amountOfSecuritiesSold>
      <grossProceeds>266341.09</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kris Hanson</name>
        <address>
          <com:street1>800 Chesapeake Drive</com:street1>
          <com:city>Redwood City</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94063</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Maplight Therapeutics, Inc.</securitiesClassTitle>
      <saleDate>07/16/2026</saleDate>
      <amountOfSecuritiesSold>8118</amountOfSecuritiesSold>
      <grossProceeds>298606.02</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kris Hanson</name>
        <address>
          <com:street1>800 Chesapeake Drive</com:street1>
          <com:city>Redwood City</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94063</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Maplight Therapeutics, Inc.</securitiesClassTitle>
      <saleDate>07/17/2026</saleDate>
      <amountOfSecuritiesSold>1130</amountOfSecuritiesSold>
      <grossProceeds>42825.76</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>All Sales are to be made pursuant to a previously signed/adopted 10b5-1 Selling plan dated 12/29/2025, and all representations regarding material non-public information were made as of the adoption of the plan. The securities to be sold were acquired upon the vesting of restricted stock units during the period of 7/30/2023 through 7/15/2026.</remarks>
    <noticeSignature>
      <noticeDate>09/16/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>12/29/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>KRISTOPHER L HANSON</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
