X0306 4 2022-08-09 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001789815 Tatsis Ourania C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Chief Reg. & Quality Off. Common Stock 2022-08-09 4 S 0 292 297.54 D 47198 D Common Stock 2022-08-09 4 S 0 679 298.77 D 46519 D Common Stock 2022-08-09 4 S 0 283 299.79 D 46236 D Common Stock 2022-08-09 4 S 0 72 300.64 D 46164 D Common Stock 2022-08-09 4 S 0 74 301.67 D 46090 D Includes 134 shares previously purchased under the issuer's Employee Stock Purchase Plan. Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1. Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $297.54 (range $297.00 to $297.80). Open market sales reported on this line occurred at a weighted average price of $298.77 (range $298.29 to $299.19). Open market sales reported on this line occurred at a weighted average price of $299.79 (range $299.44 to $300.33). /s/ Joy Liu, Attorney-in-Fact 2022-08-10