X0206 3 2019-09-16 0 0001001233 SANGAMO THERAPEUTICS, INC SGMO 0001789340 Ramelmeier Rolf Andrew 7000 MARINA BLVD. BRISBANE CA 94005 0 1 0 0 EVP, Technical Operations Common Stock 15770 D Stock Option (Right to Buy) 20.85 2018-01-30 Common Stock 120000 D Stock Option (Right to Buy) 9.03 2029-02-24 Common Stock 75000 D Includes 12,500 shares of common stock issuable upon settlement of restricted stock units ("RSUs") granted to the Reporting Person on February 25, 2019. The RSUs will vest with respect to 1/3rd of the shares in three equal annual installments over the three-year period measured from the date of grant, subject to the Reporting Person's continued service with the Issuer through such date. One-quarter (1/4) of the option shares vested and became exercisable upon completion of one (1) year of service by the Reporting Person measured from the January 31, 2018 grant date, and the remainder vest and become exercisable in equal monthly installments for thirty-six (36) months thereafter, provided that the Reporting Person remains in service with the Issuer through each such monthly vesting date. One-quarter (1/4) of the option shares vest and become exercisable upon completion of one (1) year of service by the Reporting Person measured from the February 25, 2019 grant date, and the remainder will vest and become exercisable in equal monthly installments for thirty-six (36) months thereafter, provided that the Reporting Person remains in service with the Issuer through each such monthly vesting date. /s/ Matthew Colvin, Attorney-in-Fact for Andy Ramelmeier 2019-09-26