X0306 4 2019-10-07 0001781983 Aprea Therapeutics, Inc. APRE 0001789076 Attar Eyal C. 535 BOYLSTON STREET BOSTON MA 02116 true SVP, Chief Medical Officer Common Stock 2019-10-07 4 P 0 200 15 A 200 I By adult child Common Stock 2019-10-07 4 P 0 200 15 A 200 I By child Stock Option (right to Buy) 15 2019-10-07 4 A 0 77630 0 A 2029-10-02 Common Stock 77630 77630 D The reporting person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 of the Securities Exchange Act of 1934, or for any other purpose. Twenty-five percent of these options vest on October 2, 2020, with the remaining options vesting ratably over the following 36 months, subject to the reporting person's continued employment through and including the applicable vesting date and subject to acceleration under certain conditions. /s/ Scott M. Coiante, attorney-in-fact 2019-10-07