X0306 4 2021-02-25 0001781983 Aprea Therapeutics, Inc. APRE 0001789039 Abrahmsen Lars B. 535 BOYLSTON STREET BOSTON MA 02116 true SVP, Chief Scientific Officer Common Stock 2021-02-25 4 A 0 19000 0 A 19000 D Stock Option (right to Buy) 6 2021-02-25 4 A 0 82000 0 A 2031-02-25 Common Stock 82000 82000 D These shares represent restricted stock units which were granted on February 25, 2021, and which will vest and be settled in common stock as follows: (i) 6,333 shares on February 25, 2022, (ii) 6,333 shares on February 25, 2023 and (iii) 6,334 shares on February 25, 2024, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions. Twenty-five percent of these options vest on February 25, 2022, with the remaining options vesting ratably over the following 36 months, subject to the reporting person's continued employment through and including the applicable vesting date and subject to acceleration under certain conditions. /s/ Scott M. Coiante, attorney-in-fact 2021-03-01