X0306 4 2019-10-07 0001781983 Aprea Therapeutics, Inc. APRE 0001789039 Abrahmsen Lars B. 535 BOYLSTON STREET BOSTON MA 02116 true SVP, Chief Scientific Officer Stock Option (right to Buy) 15 2019-10-07 4 A 0 77630 0 A 2029-10-02 Common Stock 77630 77630 D Twenty-five percent of these options vest on October 2, 2020, with the remaining options vesting ratably over the following 36 months, subject to the reporting person's continued employment through and including the applicable vesting date and subject to acceleration under certain conditions. /s/ Scott M. Coiante, attorney-in-fact 2019-10-07