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Stock-Based Compensation (Tables)
3 Months Ended
Mar. 31, 2026
Stock-Based Compensation [Abstract]  
Schedule of Stock Option Activities

The following table summarizes the stock option activities, including performance-based stock options, under the 2024 Plan, the 2021 Equity Incentive Plan (the “2021 Plan”), the 2022 Inducement Plan and the 2019 EIP for the three months ended March 31, 2026:

 

    Options
Outstanding
    Weighted
Average
Exercise Price
    Weighted Average
Remaining
Contractual
Life (Years)
    Aggregate
Intrinsic Value
(in thousands)
 
Balance, December 31, 2025     2,246,206     $ 13.72       4.81     $  
Options granted     1,262,300       1.65                  
Options cancelled/forfeited     (837,148 )     7.08                  
Balance, March 31, 2026     2,671,358       10.10       7.43        
Vested and expected to vest, March 31, 2026     2,671,358       10.10       7.43        
Exercisable, March 31, 2026     1,018,023       18.93       4.33        

There was no performance-based stock option activity under the 2024 Plan or the 2021 Plan during the three months ended March 31, 2026.

 

    Options
Outstanding
    Weighted
Average
Exercise Price
    Weighted
Average
Remaining
Contractual
Life (Years)
    Aggregate
Intrinsic
Value  (in thousands)
 
Balance, December 31, 2025     30,894     $ 7.33       4.43     $  
Balance, March 31, 2026     30,894     $ 7.33       4.18     $  
Vested and expected to vest, March 31, 2026     30,894     $ 7.33       4.18     $  
Exercisable, March 31, 2026     30,894     $ 7.33       4.18     $  
Schedule of RSU Activity

The following table provides a summary of RSU activity under the 2024 Plan during the three months ended March 31, 2026:

 

    Number of
Share
    Weighted-
Average
Grant Date
Fair Value
 
Unvested restricted stock units at December 31, 2025     198,900     $ 6.00  
Forfeited     (28,800 )   $ 6.00  
Unvested restricted stock units at March 31, 2026     170,100     $ 6.00  
Schedule of Stock-Based Compensation Expenses

The following table presents stock-based compensation expenses related to options, PSUs and RSUs granted to employees and non-employees, employee stock purchase plan awards and restricted common stock shares issued to founders (in thousands):

 

    Three Months Ended
March 31,
 
    2026     2025  
General and administrative   $ 202     $ 1,240  
Research and development     221       571  
Total   $ 423     $ 1,811  
Schedule of Fair Value of Stock Options Was Estimated Using a Black-Scholes Option-Pricing Model

The grant date fair value of stock options was estimated using a Black-Scholes option-pricing model with the following assumptions:

 

    Three Months Ended
March 31,
 
    2026     2025  
Expected term (in years)     6.08       6.01 – 6.08  
Expected volatility     99.87% – 100.05 %     97.37% – 97.93 %
Risk-free interest rate     3.85%  – 3.88 %     3.93% – 4.35 %
Expected dividend yield