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        <confirmingCopyFlag>false</confirmingCopyFlag>
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      <filer>
        <credentials>
          <cik>0001787423</cik>
          <ccc>XXXXXXXX</ccc>
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      <periodOfReport>03-31-2023</periodOfReport>
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      <isAmendment>true</isAmendment>
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      <filingManager>
        <name>Madryn Asset Management, LP</name>
        <address>
          <com:street1>330 MADISON AVENUE</com:street1>
          <com:street2>33RD FLOOR</com:street2>
          <com:city>NEW YORK</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
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      <provideInfoForInstruction5>N</provideInfoForInstruction5>
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    <signatureBlock>
      <name>MATTHEW GIRANDOLA</name>
      <title>CHIEF COMPLIANCE OFFICER</title>
      <phone>(646) 560-5490</phone>
      <signature>MATTHEW GIRANDOLA</signature>
      <city>NEW YORK</city>
      <stateOrCountry>NY</stateOrCountry>
      <signatureDate>05-12-2023</signatureDate>
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