CONDENSED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2026	Sep. 30, 2025	Sep. 30, 2026	Sep. 30, 2025
Cash flows from operating activities:
Net loss			$ (101,526,000)	$ (76,675,000)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	$ 1,765,000	$ 1,773,000	5,528,000	6,660,000
Depreciation and amortization	2,056,000	2,306,000	7,128,000	6,936,000
Accretion and amortization of premiums and (discounts) on investments, net			(1,472,000)	(3,725,000)
Realized gain on investments				(43,000)
Impairment of property and equipment	0	0	5,670,000	0
Impairment of right-of-use asset	0	791,000	2,378,000	791,000
Non-cash lease expense			1,551,000	1,428,000
Changes in operating assets and liabilities:
Prepaid expenses and other assets			1,490,000	1,278,000
Operating lease liabilities			(4,383,000)	(3,639,000)
Accounts payable and accrued and other liabilities			5,378,000	(63,000)
Net cash used in operating activities			(78,258,000)	(67,052,000)
Cash flows from investing activities:
Purchases of property and equipment			(1,841,000)	(648,000)
Sale of equipment			100,000
Purchases of investments			(106,301,000)	(147,149,000)
Maturities of investments			194,195,000	247,013,000
Net cash provided by investing activities			86,153,000	99,216,000
Cash flows from financing activities:
Proceeds from stock option exercises			752,000
Proceeds from employee stock purchase plan purchases			73,000	77,000
Net cash provided by financing activities			825,000	77,000
Net increase in cash, cash equivalents, and restricted cash			8,720,000	32,241,000
Cash, cash equivalents, and restricted cash beginning of period			42,377,000	30,616,000
Cash, cash equivalents, and restricted cash end of period	51,097,000	62,857,000	51,097,000	62,857,000
Reconciliation of cash, cash equivalents and restricted cash to the balance sheet:
Cash and cash equivalents	48,354,000	60,114,000	48,354,000	60,114,000
Restricted cash	2,743,000	2,743,000	2,743,000	2,743,000
Total cash, cash equivalents and restricted cash	$ 51,097,000	$ 62,857,000	51,097,000	62,857,000
Supplemental disclosures of non-cash investing and financing activities:
Acquisitions of property and equipment in accounts payable and accrued and other current liabilities			$ 221,000	$ 155,000