Segment Reporting - Summary of Reconciliation to Net Loss (Details) - USD ($) $ in Thousands		3 Months Ended
		Mar. 31, 2026	Mar. 31, 2025
Segment expenses:
Total operating expenses		$ 30,876	$ 36,564
Reconciling items:
Depreciation and amortization		(2,340)	(2,299)
Share-based compensation		(1,898)	(2,834)
Interest income		2,838	4,376
Other income, net		206	205
Net loss		(27,832)	(31,983)
Segment
Segment expenses:
Personnel related expenses, excluding share-based compensation	[1]	8,767	15,896
Facilities expenses		4,393	4,565
Direct external development program expenses		7,479	5,420
Other segment expenses	[2]	5,999	5,550
Total operating expenses		26,638	31,431
Reconciling items:
Net loss		$ (26,638)	$ (31,431)

[1] Personnel related expenses include $5.1 million of severance and other benefits expense for the three months ended March 31, 2025, respectively.

[2] Other segment items include consultants and contractor, lab supplies, and general business expenses.