Segment Reporting - Summary of Reconciliation to Net Loss (Details) - USD ($)		12 Months Ended
		Dec. 31, 2024	Dec. 31, 2023
Segment expenses:
Total operating expenses		$ 128,194,000	$ 131,650,000
Net loss		(108,790,000)	(117,501,000)
Reconciling items:
Depreciation and amortization		(9,152,000)	(5,869,000)
Share-based compensation		(16,731,000)	(17,199,000)
Impairment of ROU asset		0	(4,100,000)
Interest income		19,317,000	14,107,000
Other income, net		87,000	42,000
Segment
Segment expenses:
Personnel related expenses, excluding share-based compensation		41,129,000	42,329,000
Facilities expenses		19,403,000	16,392,000
Direct external development program expenses		21,431,000	29,517,000
Other segment expenses	[1]	20,348,000	16,244,000
Total operating expenses		102,311,000	104,482,000
Net loss		$ (102,311,000)	$ (104,482,000)

[1] Other segment items include consultants and contractor, lab supplies, and general business expenses.