Leases - Additional Information (Details) - USD ($)	1 Months Ended						12 Months Ended
	Dec. 31, 2024	Jun. 30, 2023	Oct. 31, 2021	Jan. 31, 2021	May 31, 2020	May 31, 2018	Dec. 31, 2024	Dec. 31, 2023	Jul. 31, 2021
Lessee Lease Description [Line Items]
Weighted-average discount rate	9.80%						9.80%
Lessee, operating lease, term of contract									12 years
Lease liabilities	$ 80,273,000						$ 80,273,000
Right-of-use assets	$ 36,014,000						36,014,000	$ 39,949,000
Additional tenant improvement allowances		$ 4,400,000
Tenant improvement costs in equal monthly payments annual rate		8.50%
ROU asset impairment							$ 0	$ 4,100,000
Estimated subtenant rate	8.00%						8.00%
Third amendment
Lessee Lease Description [Line Items]
Operating lease, description							The lease amendment for this additional space commenced in April 2021 and expired in March 2024.
Lease expiration month and year				2024-03
Initial Lease Agreement
Lessee Lease Description [Line Items]
Operating lease, existence of option to extend			true		true
Lease expiration year						2025
Initial Lease Agreement | Sixth Amendment
Lessee Lease Description [Line Items]
Termination fee payment to landlord	$ 600,000						$ 1,100,000
Decrease in right-of-use asset	2,200,000
Decrease in lease liability	$ 2,200,000
Corporate Office and Laboratory Space
Lessee Lease Description [Line Items]
Weighted-average remaining lease term	9 years						9 years
Corporate Office and Laboratory Space | Sixth Amendment
Lessee Lease Description [Line Items]
Lessee option to extend description	In December 2024, the Company executed a sixth amendment to the Initial Lease Agreement, which updated the lease termination date for one of the spaces in the same building to July 31, 2025.
Corporate Office and Laboratory Space | Initial Lease Agreement
Lessee Lease Description [Line Items]
Renewal term						7 years
Operating lease, existence of option to extend						true
Lessee option to extend description							In April 2019, the Company executed the first amendment to the Initial Lease Agreement for additional corporate space, laboratory space and manufacturing capabilities.