CONDENSED STATEMENT OF CASH FLOWS (Unaudited) - USD ($)	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Cash flows from operating activities
Net loss	$ (54,511,000)	$ (64,102,000)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	8,782,000	9,396,000
Depreciation and amortization	4,517,000	1,636,000
Accretion and amortization of premiums and discounts on investments, net	(3,021,000)	(4,511,000)
Realized gain on investments	0	(34,000)
Impairment of right-of-use assets	0	4,100,000
Non-cash lease expense	1,154,000	1,100,000
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(1,833,000)	663,000
Operating lease liabilities	(3,345,000)	7,143,000
Accounts payable and accrued and other liabilities	(2,143,000)	2,078,000
Net cash used in operating activities	(50,400,000)	(42,531,000)
Cash flows from investing activities
Purchases of property and equipment	(2,529,000)	(15,151,000)
Purchases of investments	(214,311,000)	(157,486,000)
Maturities of investments	130,700,000	206,395,000
Net cash (used in) provided by investing activities	(86,140,000)	33,758,000
Cash flows from financing activities
Proceeds from stock option exercises	667,000	22,000
Proceeds from ESPP purchases	158,000	374,000
Proceeds from issuance of common stock and pre-funded warrants, net of issuance costs	225,073,000
Net cash provided by financing activities	225,898,000	396,000
Net increase (decrease) in cash and cash equivalents	89,358,000	(8,377,000)
Cash, cash equivalents, and restricted cash beginning of period	33,783,000	40,237,000
Cash, cash equivalents, and restricted cash end of period	123,141,000	31,860,000
Reconciliation of cash, cash equivalents and restricted cash to the balance sheet:
Cash and cash equivalents	120,398,000	29,117,000
Restricted cash	2,743,000	2,743,000
Total cash, cash equivalents and restricted cash	123,141,000	31,860,000
Supplemental disclosures of non-cash investing activities:
Right-of-use assets obtained in exchange for operating lease liabilities resulting from new leases	579,000	431,000
Stock issuance costs included in accrued and other current liabilities	4,000
Acquisitions of property and equipment in accounts payable and accrued and other current liabilities	$ 213,000	$ 690,000