Insider Trading Arrangements	3 Months Ended
Mar. 31, 2024 shares
Trading Arrangements, by Individual
Material Terms of Trading Arrangement	On March 28, 2024, Paul Hastings, Chief Executive Officer, adopted a trading arrangement for the sale of shares of our common stock (a "Rule 10b5-1 Trading Plan") that is intended to satisfy the affirmative defense conditions of Exchange Act Rule 10b5-1(c). Mr. Hastings’ Rule 10b5-1 Trading Plan provides for the sale of up to 439,061 shares of common stock (including shares obtained from the exercise of vested stock options and the associated sale of such shares) pursuant to the terms of the plan. The first possible trade date under Mr. Hastings’ Rule 10b5-1 Trading Plan is June 27, 2024, and the plan is effective through June 27, 2025 unless earlier terminated in accordance with the terms of the plan. On March 15, 2024, Mr. Hastings terminated his prior Rule 10b5-1 Trading Plan originally adopted on June 27, 2022, for the sale of up to 340,000 shares of common stock, subject to certain conditions, until July 31, 2024, of which 160,000 shares remained unsold at the date his prior Rule 10b5-1 Trading Plan was terminated. On March 28, 2024, Alyssa Levin, Chief Financial and Business Officer, adopted a Rule 10b5-1 Trading Plan that is intended to satisfy the affirmative defense conditions of Exchange Act Rule 10b5-1(c). Ms. Levin’s Rule 10b5-1 Trading Plan provides for the sale of up to 110,600 shares of common stock (including shares obtained from the exercise of vested stock options and the associated sale of such shares), as well as 100% of the net shares of common stock resulting from the vesting of previously-awarded restricted stock units covering 28,000 shares of common stock, in each case pursuant to the terms of the plan. The first possible trade date under Ms. Levin’s Rule 10b5-1 Trading Plan is July 1, 2024, and the plan is effective through June 26, 2026 unless earlier terminated in accordance with the terms of the plan. On March 28, 2024, Alicia Hager, Chief Legal Officer, adopted a Rule 10b5-1 Trading Plan that is intended to satisfy the affirmative defense conditions of Exchange Act Rule 10b5-1(c). Dr. Hager’s Rule 10b5-1 Trading Plan provides for the sale of up to 216,025 shares of common stock (including shares obtained from the exercise of vested stock options and the associated sale of such shares), ,as well as 100% of the net shares of common stock resulting from the vesting of previously-awarded restricted stock units covering 30,575 shares of common stock, in each case pursuant to the terms of the plan. The first possible trade date under Dr. Hager’s Rule 10b5-1 Trading Plan is June 27, 2024, and the plan is effective through November 13, 2025 unless earlier terminated in accordance with the terms of the plan. On March 28, 2024, Ralph Brandenberger, Chief Technical Officer, adopted a Rule 10b5-1 Trading Plan that is intended to satisfy the affirmative defense conditions of Exchange Act Rule 10b5-1(c). Dr. Brandenberger’s Rule 10b5-1 Trading Plan provides for the sale of up to 36,062 shares of common stock (including shares obtained from the exercise of vested stock options and the associated sale of such shares), subject to certain conditions, as well as 100% of the net shares of common stock resulting from the vesting of previously-awarded restricted stock units covering 43,025 shares of common stock, in each case pursuant to the terms of the plan. The first possible trade date under Dr. Brandenberger’s Rule 10b5-1 Trading Plan is July 1, 2024, and the plan is effective through June 26, 2026 unless earlier terminated in accordance with the terms of the plan. On March 28, 2024, Leone Patterson, director and chairperson of the audit committee of the Company's Board of Directors, adopted a Rule 10b5-1 Trading Plan that is intended to satisfy the affirmative defense conditions of Exchange Act Rule 10b5-1(c). Ms. Patterson’s Rule 10b5-1 Trading Plan provides for the sale of up to 39,729 shares of common stock (including shares obtained from the exercise of vested stock options and the associated sale of such shares) pursuant to the terms of the plan. The first possible trade date under Ms. Patterson’s Rule 10b5-1 Trading Plan is June 27, 2024, and the plan is effective through June 19, 2026 unless earlier terminated in accordance with the terms of the plan.
Rule 10b5-1 Arrangement Adopted	false
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Non-Rule 10b5-1 Arrangement Terminated	false
Rule 10b5-1 Arrangement Modified	false
Non-Rule 10b5-1 Arrangement Modified	false
Paul Hastings
Trading Arrangements, by Individual
Name	Paul Hastings
Title	Chief Executive Officer
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	March 28, 2024
Rule 10b5-1 Arrangement Terminated	true
Termination Date	March 15, 2024
Aggregate Available	439,061
Paul Hastings
Trading Arrangements, by Individual
Aggregate Available	340,000
Alyssa Levin
Trading Arrangements, by Individual
Name	Alyssa Levin
Title	Chief Financial and Business Officer
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	March 28, 2024
Rule 10b5-1 Arrangement Terminated	true
Termination Date	June 26, 2026
Aggregate Available	110,600
Alicia Hager
Trading Arrangements, by Individual
Name	Alicia Hager
Title	Chief Legal Officer
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	March 28, 2024
Rule 10b5-1 Arrangement Terminated	true
Termination Date	November 13, 2025
Aggregate Available	216,025
Ralph Brandenberger
Trading Arrangements, by Individual
Name	Ralph Brandenberger
Title	Chief Technical Officer
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	March 28, 2024
Rule 10b5-1 Arrangement Terminated	true
Termination Date	June 26, 2026
Aggregate Available	36,062
Leone Patterson
Trading Arrangements, by Individual
Name	Leone Patterson
Title	director and chairperson
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	March 28, 2024
Rule 10b5-1 Arrangement Terminated	true
Termination Date	June 19, 2026
Aggregate Available	39,729

Insider Trading Arrangements

3 Months Ended

Mar. 31, 2024

On March 28, 2024, Paul Hastings, Chief Executive Officer, adopted a trading arrangement for the sale of

shares of our common stock (a "Rule 10b5-1 Trading Plan") that is intended to satisfy the affirmative defense conditions of Exchange Act Rule 10b5-1(c). Mr. Hastings’ Rule 10b5-1 Trading Plan provides for the sale of up to 439,061 shares of common stock (including shares obtained from the exercise of vested stock options and the associated sale of such shares) pursuant to the terms of the plan. The first possible trade date under Mr. Hastings’ Rule 10b5-1 Trading Plan is June 27, 2024, and the plan is effective through June 27, 2025 unless earlier terminated in accordance with the terms of the plan. On March 15, 2024, Mr. Hastings terminated his prior Rule 10b5-1 Trading Plan originally adopted on June 27, 2022, for the sale of up to 340,000 shares of common stock, subject to certain conditions, until July 31, 2024, of which 160,000 shares remained unsold at the date his prior Rule 10b5-1 Trading Plan was terminated.

On March 28, 2024, Alyssa Levin, Chief Financial and Business Officer, adopted a Rule 10b5-1 Trading Plan that is intended to satisfy the affirmative defense conditions of Exchange Act Rule 10b5-1(c). Ms. Levin’s Rule 10b5-1 Trading Plan provides for the sale of up to 110,600 shares of common stock (including shares obtained from the exercise of vested stock options and the associated sale of such shares), as well as 100% of the net shares of common stock resulting from the vesting of previously-awarded restricted stock units covering 28,000 shares of common stock, in each case pursuant to the terms of the plan. The first possible trade date under Ms. Levin’s Rule 10b5-1 Trading Plan is July 1, 2024, and the plan is effective through June 26, 2026 unless earlier terminated in accordance with the terms of the plan.

On March 28, 2024, Alicia Hager, Chief Legal Officer, adopted a Rule 10b5-1 Trading Plan that is intended to satisfy the affirmative defense conditions of Exchange Act Rule 10b5-1(c). Dr. Hager’s Rule 10b5-1 Trading Plan provides for the sale of up to 216,025 shares of common stock (including shares obtained from the exercise of vested stock options and the associated sale of such shares), ,as well as 100% of the net shares of common stock resulting from the vesting of previously-awarded restricted stock units covering 30,575 shares of common stock, in each case pursuant to the terms of the plan. The first possible trade date under Dr. Hager’s Rule 10b5-1 Trading Plan is June 27, 2024, and the plan is effective through November 13, 2025 unless earlier terminated in accordance with the terms of the plan.

On March 28, 2024, Ralph Brandenberger, Chief Technical Officer, adopted a Rule 10b5-1 Trading Plan that is intended to satisfy the affirmative defense conditions of Exchange Act Rule 10b5-1(c). Dr. Brandenberger’s Rule 10b5-1 Trading Plan provides for the sale of up to 36,062 shares of common stock (including

shares obtained from the exercise of vested stock options and the associated sale of such shares), subject to certain conditions, as well as 100% of the net shares of common stock resulting from the vesting of previously-awarded restricted stock units covering 43,025 shares of common stock, in each case pursuant to the terms of the plan. The first possible trade date under Dr. Brandenberger’s Rule 10b5-1 Trading Plan is July 1, 2024, and the plan is effective through June 26, 2026 unless earlier terminated in accordance with the terms of the plan.

On March 28, 2024, Leone Patterson, director and chairperson of the audit committee of the Company's Board

of Directors, adopted a Rule 10b5-1 Trading Plan that is intended to satisfy the affirmative defense conditions of Exchange Act Rule 10b5-1(c). Ms. Patterson’s Rule 10b5-1 Trading Plan provides for the sale of up to 39,729 shares of common stock (including shares obtained from the exercise of vested stock options and the associated sale of such shares) pursuant to the terms of the plan. The first possible trade date under Ms. Patterson’s Rule 10b5-1 Trading Plan is June 27, 2024, and the plan is effective through June 19, 2026 unless earlier terminated in accordance with the terms of the plan.