CONDENSED STATEMENT OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities
Net loss	$ (81,255)	$ (63,261)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	12,399	10,729
Depreciation and amortization	1,908	1,200
Accretion and amortization of premiums and discounts on investments, net	763	2,410
Non-cash lease expense	3,269	324
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(1,575)	(3,688)
Operating lease liabilities	11,446
Accounts payable and accrued and other liabilities	3,376	1,931
Net cash used in operating activities	(49,669)	(50,355)
Cash flows from investing activities
Purchases of property and equipment	(12,073)	(3,932)
Purchases of short-term investments	(310,313)	(131,109)
Maturities of short-term investments	132,950	185,410
Net cash used in investing activities	(189,436)	50,369
Cash flows from financing activities
Proceeds from stock option exercises	1,365	1,330
Proceeds from secondary offering, net of issuance costs	215,611
Proceeds from ATM offering, net of issuance costs	1,612
Payments of deferred offering costs		(130)
Net cash provided by financing activities	218,588	1,200
Net increase (decrease) in cash and cash equivalents	(20,517)	1,214
Cash, cash equivalents, and restricted cash beginning of period	62,914	97,105
Cash, cash equivalents, and restricted cash end of period	42,397	98,319
Reconciliation of cash, cash equivalents and restricted cash to the balance sheet:
Cash and cash equivalents	39,654	96,221
Restricted cash	2,743	2,098
Total cash, cash equivalents and restricted cash	42,397	98,319
Supplemental disclosures of non-cash investing and financing activities:
Right-of-use assets obtained in exchange for operating lease liabilities resulting from new leases	59,527
Right-of-use assets obtained in exchange for operating lease liabilities resulting from modifications of existing leases	14,793
Acquisitions of property and equipment in accounts payable	$ 7,228	$ 69