Share-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2022

Share-Based Payment Arrangement [Abstract]

Summary of Stock Option Activity

The following table summarizes the option activity under the 2020 Plan and 2015 Plan during the six months ended June 30, 2022:

	Number of shares			Weighted- average exercise price		Weighted- average remaining contractual term (in years)
Outstanding at December 31, 2021		4,204,686		$	19.19		8.2
Granted		1,642,598			12.51
Exercised		(109,450	)		3.76
Forfeited		(480,080	)		20.47
Outstanding at June 30, 2022		5,257,754		$	17.31		8.0
Exercisable at June 30, 2022		2,078,037		$	16.32		6.8
Vested and expected to vest at June 30, 2022		5,257,754		$	17.31		8.0

Summary of Restricted Stock Unit Activity

The following table summarizes the restricted stock unit activity under the 2020 Plan during the six months ended June 30, 2022:

	Number of shares			Weighted-average grant date fair value per share
Outstanding at December 31, 2021		—		$	—
Granted		356,908			12.18
Forfeited		(36,630	)		12.14
Vested		—			—
Outstanding at June 30, 2022		320,278		$	12.18

Summary of Share-based Compensation Expense

Share-based compensation expense for the three and six months ended June 30, 2022 and 2021 was as follows (in thousands):

	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
Research and development	$	1,602	$	1,744	$	3,457	$	3,314
General and administrative		2,310		1,946		4,552		3,723
Total share-based compensation	$	3,912	$	3,690	$	8,009	$	7,037