X0306 4 2022-08-08 0 0001787400 Nkarta, Inc. NKTX 0001853197 Brandenberger Ralph C/O NKARTA, INC., 6000 SHORELINE COURT, SUITE 102 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Technical Officer Common Stock 2022-08-08 4 M 0 4367 0.41 A 12167 D Common Stock 2022-08-08 4 M 0 6886 3.89 A 19053 D Common Stock 2022-08-08 4 M 0 340 4.77 A 19393 D Common Stock 2022-08-08 4 S 0 11593 15.5079 D 7800 D Stock Option (right to buy) 0.41 2022-08-08 4 M 0 4367 0.00 D 2028-07-18 Common Stock 4367 0 D Stock Option (right to buy) 3.89 2022-08-08 4 M 0 6886 0.00 D 2029-09-05 Common Stock 6886 37253 D Stock Option (right to buy) 4.77 2022-08-08 4 M 0 340 0.00 D 2029-05-10 Common Stock 340 8445 D The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person at least 30 days prior to the trade date. This transaction was executed in multiple trades at prices ranging from $15.00 to $16.00. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected. This stock option is fully vested. The options exercised were fully vested. Unvested options will vest and become exercisable ratably in monthly installments until fully vested on September 5, 2023. The options exercised were fully vested. Unvested options will vest and become exercisable ratably in monthly installments until fully vested on December 6, 2022. /s/ Alicia Hager, as Attorney-in-Fact 2022-08-10