<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001798679</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001787306</issuerCik>
      <issuerName>ARCUTIS BIOTHERAPEUTICS, INC.</issuerName>
      <secFileNumber>001-39186</secFileNumber>
      <issuerAddress>
        <com:street1>3027 Townsgate Road Suite 300</com:street1>
        <com:city>Westlake Village</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>91361</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>805418-5006</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Masaru Matsuda</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>8890 Lyra Drive 5th Floor</com:street1>
          <com:city>Columbus</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>43240</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>12058</noOfUnitsSold>
      <aggregateMarketValue>313878</aggregateMarketValue>
      <noOfUnitsOutstanding>124033382</noOfUnitsOutstanding>
      <approxSaleDate>03/02/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/01/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6746</amountOfSecuritiesAcquired>
      <paymentDate>03/01/2026</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/27/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>3325</amountOfSecuritiesAcquired>
      <paymentDate>02/27/2025</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/02/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1987</amountOfSecuritiesAcquired>
      <paymentDate>03/02/2025</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Masaru Matsuda</name>
        <address>
          <com:street1>3027 Townsgate Rd Suite 300</com:street1>
          <com:city>Westlake Village</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91361</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>12/01/2025</saleDate>
      <amountOfSecuritiesSold>1675</amountOfSecuritiesSold>
      <grossProceeds>50041</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Masaru Matsuda</name>
        <address>
          <com:street1>3027 Townsgate Rd Suite 300</com:street1>
          <com:city>Westlake Village</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91361</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/02/2026</saleDate>
      <amountOfSecuritiesSold>40638</amountOfSecuritiesSold>
      <grossProceeds>1027275</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Masaru Matsuda</name>
        <address>
          <com:street1>3027 Townsgate Rd Suite 300</com:street1>
          <com:city>Westlake Village</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91361</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/27/2026</saleDate>
      <amountOfSecuritiesSold>3325</amountOfSecuritiesSold>
      <grossProceeds>92933.75</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>5312 shares were sold pursuant to10b5-1 plan</remarks>
    <noticeSignature>
      <noticeDate>03/02/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>06/06/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>Masaru Matsuda</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
