<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001801061</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001787306</issuerCik>
      <issuerName>Arcutis Biotherapeutics, Inc.</issuerName>
      <secFileNumber>001-39186</secFileNumber>
      <issuerAddress>
        <com:street1>3027 TOWNSGATE ROAD SUITE 300</com:street1>
        <com:city>WESTLAKE VILLAGE</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>91361</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>805-418-5006</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Todd Franklin Watanabe</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>8890 Lyra Drive 5th Floor</com:street1>
          <com:city>Columbus</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>43240</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>24261</noOfUnitsSold>
      <aggregateMarketValue>469074</aggregateMarketValue>
      <noOfUnitsOutstanding>119905078</noOfUnitsOutstanding>
      <approxSaleDate>10/01/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>08/01/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>14018</amountOfSecuritiesAcquired>
      <paymentDate>08/01/2025</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/01/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>3988</amountOfSecuritiesAcquired>
      <paymentDate>05/01/2025</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/01/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6255</amountOfSecuritiesAcquired>
      <paymentDate>03/01/2025</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Todd Franklin Watanabe</name>
        <address>
          <com:street1>3027 Townsgate Rd Suite 300</com:street1>
          <com:city>Westlake Village</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91361</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>09/09/2025</saleDate>
      <amountOfSecuritiesSold>504</amountOfSecuritiesSold>
      <grossProceeds>8829</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Todd Franklin Watanabe</name>
        <address>
          <com:street1>3027 Townsgate Rd Suite 300</com:street1>
          <com:city>Westlake Village</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91361</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>09/08/2025</saleDate>
      <amountOfSecuritiesSold>9625</amountOfSecuritiesSold>
      <grossProceeds>168800</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Todd Franklin Watanabe</name>
        <address>
          <com:street1>3027 Townsgate Rd Suite 300</com:street1>
          <com:city>Westlake Village</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91361</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>08/04/2025</saleDate>
      <amountOfSecuritiesSold>11547</amountOfSecuritiesSold>
      <grossProceeds>165429</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>10/01/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>06/03/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>Todd Watanabe</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
