<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001801050</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001787306</issuerCik>
      <issuerName>Arcutis Biotherapeutics</issuerName>
      <secFileNumber>001-39186</secFileNumber>
      <issuerAddress>
        <com:street1>3027 TownsgateRd Ste300</com:street1>
        <com:city>Westlake Village</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>91361</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>8054185006</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Howard Welgus</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill</name>
        <address>
          <com:street1>8890 Lyra Dr 5th Flr</com:street1>
          <com:city>Columbus</com:city>
          <com:stateOrCountry>OH</com:stateOrCountry>
          <com:zipCode>43215</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>10000</noOfUnitsSold>
      <aggregateMarketValue>189227</aggregateMarketValue>
      <noOfUnitsOutstanding>119905078</noOfUnitsOutstanding>
      <approxSaleDate>10/01/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/04/2018</acquiredDate>
      <natureOfAcquisitionTransaction>Stock option exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>462</amountOfSecuritiesAcquired>
      <paymentDate>06/04/2018</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>04/16/2021</acquiredDate>
      <natureOfAcquisitionTransaction>restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2159</amountOfSecuritiesAcquired>
      <paymentDate>04/16/2021</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/21/2021</acquiredDate>
      <natureOfAcquisitionTransaction>restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1612</amountOfSecuritiesAcquired>
      <paymentDate>05/21/2021</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/27/2022</acquiredDate>
      <natureOfAcquisitionTransaction>restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2250</amountOfSecuritiesAcquired>
      <paymentDate>02/27/2022</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/27/2023</acquiredDate>
      <natureOfAcquisitionTransaction>restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2250</amountOfSecuritiesAcquired>
      <paymentDate>02/27/2023</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/01/2023</acquiredDate>
      <natureOfAcquisitionTransaction>restricted stock vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Arcutis Biotherapeutics Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1267</amountOfSecuritiesAcquired>
      <paymentDate>06/01/2023</paymentDate>
      <natureOfPayment>na</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Howard Welgus</name>
        <address>
          <com:street1>3027 Townsgate Rd Ste 300</com:street1>
          <com:city>Westlake Village</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91361</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>09/02/2025</saleDate>
      <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
      <grossProceeds>156383</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Howard Welgus</name>
        <address>
          <com:street1>3027 Townsgate Rd Ste 300</com:street1>
          <com:city>Westlake Village</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>91361</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>08/01/2025</saleDate>
      <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
      <grossProceeds>142982</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>10/01/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>03/11/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>Howard Welgus</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
