X0306 4 2022-05-27 0 0001787306 Arcutis Biotherapeutics, Inc. ARQT 0001798679 Matsuda Masaru C/O ARCUTIS BIOTHERAPEUTICS, INC. 3027 TOWNSGATE ROAD, SUITE 300 WESTLAKE VILLAGE CA 91361 0 1 0 0 SVP and General Counsel Common Stock 2022-05-27 4 A 0 4875 0 A 18175 D Common Stock 2022-06-02 4 S 0 1795 19.7318 D 16380 D Represents performance stock units ("PSUs") initially granted on January 3, 2022 that were subject to a performance-based vesting condition. The vesting condition was determined to be satisfied on May 27, 2022. The PSUs will vest fully on May 27, 2025, subject to the Reporting Person's continued service to the Issuer on such vesting date. Includes 13,300 RSUs. Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the PSUs, the shares were sold upon the vesting of the PSUs solely to cover applicable withholding taxes. The transaction was executed in multiple trades in prices ranging from $19.7201 to $19.75, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. /s/ Scott Burrows, as Attorney-in-Fact for Matsuda Masaru 2022-06-02