X0306 4 2022-08-05 0 0001787306 Arcutis Biotherapeutics, Inc. ARQT 0001655827 Frazier Life Sciences VIII, L.P. 70 WILLOW ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001698755 FHM LIFE SCIENCES VIII, L.P. 70 WILLOW ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001698823 FHM LIFE SCIENCES VIII, L.L.C. 70 WILLOW ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001341382 Topper James N 70 WILLOW ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001365617 Heron Patrick J 70 WILLOW ROAD, SUITE 200 MENLO PARK CA 94025 1 0 1 0 Common Stock 2022-08-05 4 P 0 250000 20.00 A 8684232 D Common Stock 7 I By FHM Life Sciences VIII, L.L.C. Common Stock 11266 I By Topper Group II LLC. Common Stock 19381 I By Topper Family Revocable Trust Common Stock 23688 I By The Heron Living Trust 11/30/2004 Represents shares held of record by FHM Life Sciences VIII, L.L.C. Dr. Topper and Mr. Heron are the sole managing members of FHM Life Sciences VIII, L.L.C. and share voting and investment power of the securities held by FHM Life Sciences VIII, L.L.C. Dr. Topper and Mr. Heron disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein. Dr. Topper is a manager of Topper Group II LLC and shares voting and investment power over the shares held by Topper Group II LLC. Dr. Topper is a trustee of the Topper Family Revocable Trust and has voting and investment power over the shares held by Topper Family Revocable Trust. Mr. Heron is the co-trustee of The Heron Living Trust 11/30/2004 and has voting and investment power of the securities held by The Heron Living Trust 11/30/2004. Frazier Life Sciences VIII, L.P., By: FHM Life Sciences VIII, L.P., its general partner, By: FHM Life Sciences VIII, L.L.C., its general, partner, By: /s/ Steve R. Bailey, Chief Financial Officer 2022-08-09 FHM Life Sciences VIII, L.P., By: FHM Life Sciences VIII, L.L.C., its general, partner, By: /s/ Steve R. Bailey, Chief Financial Officer 2022-08-09 FHM Life Sciences VIII, L.L.C., By: /s/ Steve R. Bailey, Chief Financial Officer 2022-08-09 /s/ Steve R. Bailey, Attorney-in-Fact for James Topper 2022-08-09 /s/ Steve R. Bailey, Attorney-in-Fact for Patrick Heron 2022-08-09