X0306 4 2021-05-10 0 0001787306 Arcutis Biotherapeutics, Inc. ARQT 0001655827 Frazier Life Sciences VIII, L.P. 601 UNION STREET, SUITE 3200 SEATTLE WA 98101 0 0 1 0 0001698823 FHM LIFE SCIENCES VIII, L.L.C. 601 UNION STREET, SUITE 3200 SEATTLE WA 98101 0 0 1 0 0001365617 Heron Patrick J 601 UNION STREET, SUITE 3200 SEATTLE WA 98101 1 0 1 0 0001341382 Topper James N 601 UNION STREET, SUITE 3200 SEATTLE WA 98101 0 0 1 0 0001698755 FHM LIFE SCIENCES VIII, L.P. 601 UNION STREET, SUITE 3200 SEATTLE WA 98101 0 0 1 0 Common Stock 2021-05-10 4 J 0 2108558 0.00 D 8434232 D Common Stock 2021-05-10 4 J 0 96574 0.00 A 96574 I By FHM Life Sciences VIII, L.P. Common Stock 2021-05-10 4 J 0 96574 0.00 D 0 I By FHM Life Sciences VIII, L.P. Common Stock 7 I By FHM Life Sciences VIII, L.L.C. Common Stock 11266 I By Topper Group II LLC. Common Stock 19381 I By Topper Family Revocable Trust Common Stock 23688 I By The Heron Living Trust 11/30/2004 Represents a pro rata in-kind stock distribution by Frazier Life Sciences VIII, L.P. ("FLS VIII") to its limited partners and general partner for no consideration. Represents shares held of record by FLS VIII. The general partner of FLS VIII is FHM Life Sciences VIII, L.P., and the general partner of FHM Life Sciences VIII, L.P. is FHM Life Sciences VIII, L.L.C. James Topper and Patrick Heron are the sole managing members of FHM Life Sciences VIII, L.L.C. and share voting and investment power of the securities held by FLS VIII. Dr. Topper and Dr. Heron disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein. Reflects shares of Common Stock received from FLS VIII in the in-kind stock distribution described herein. Represents shares held of record by FHM Life Sciences VIII, L.P. The general partner of FHM Life Sciences VIII, L.P. is FHM Life Sciences VIII, L.L.C. Dr. Topper and Dr. Heron are the sole managing members of FHM Life Sciences VIII, L.L.C. and share voting and investment power of the securities held by FHM Life Sciences VIII, L.P. Dr. Topper and Dr. Heron disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein. Represents a pro rata in-kind stock distribution by FHM Life Sciences VIII, L.P. to its limited partners for no consideration. Reflects shares of Common Stock received from FHM Life Sciences VIII, L.P. in the in-kind stock distribution described herein. Represents shares held of record by FHM Life Sciences VIII, L.L.C. Dr. Topper and Dr. Heron are the sole managing members of FHM Life Sciences VIII, L.L.C. and share voting and investment power of the securities held by FHM Life Sciences VIII, L.L.C. Dr. Topper and Dr. Heron disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein. Dr. Topper is a manager of Topper Group II LLC and shares voting and investment power over the shares held by Topper Group II LLC. Dr. Topper is a trustee of the Topper Family Revocable Trust and has voting and investment power over the shares held by Topper Family Revocable Trust. Dr. Heron is the co-trustee of The Heron Living Trust 11/30/2004 and has voting and investment power of the securities held by The Heron Living Trust 11/30/2004. Frazier Life Sciences VIII, L.P., By: FHM Life Sciences VIII, L.P., its general partner, By: FHM Life Sciences VIII, L.L.C., its general, partner, By: /s/ Steve R. Bailey, Chief Financial Officer 2021-05-12 FHM Life Sciences VIII, L.L.C., By: /s/ Steve R. Bailey, Chief Financial Officer 2021-05-12 /s/ Steve R. Bailey, Attorney-in-Fact for Patrick Heron 2021-05-12 /s/ Steve R. Bailey, Attorney-in-Fact for James Topper 2021-05-12 FHM Life Sciences VIII, L.P., By: FHM Life Sciences VIII, L.L.C., its general, partner, By: /s/ Steve R. Bailey, Chief Financial Officer 2021-05-12