X0508 4 2026-01-21 false 0001710072 Edgewise Therapeutics, Inc. EWTX 0001786966 Edris Badreddin C/O EDGEWISE THERAPEUTICS, INC. 1715 38TH STREET BOULDER CO 80301 true false false false true Common Stock 2026-01-21 4 M false 13690.00 0.39 A 33510.00 D Common Stock 2026-01-21 4 M false 17236.00 0.64 A 50746.00 D Common Stock 2026-01-21 4 M false 10463.00 1.93 A 61209.00 D Common Stock 2026-01-21 4 M false 66477.00 1.93 A 127686.00 D Common Stock 2026-01-21 4 M false 7605.00 0.71 A 135291.00 D Common Stock 2026-01-21 4 S false 13690.00 29.44 D 121601.00 D Common Stock 2026-01-21 4 S false 17236.00 29.44 D 104365.00 D Common Stock 2026-01-21 4 S false 7605.00 29.44 D 96760.00 D Common Stock 2026-01-21 4 S false 10463.00 29.44 D 86297.00 D Common Stock 2026-01-21 4 S false 66477.00 29.44 D 19820.00 D Stock Option (Right to Buy) 1.93 2026-01-21 4 M false 10463.00 0.00 D 2024-12-03 2030-12-15 Common Stock 10463.00 0.00 D Stock Option (Right to Buy) 1.93 2026-01-21 4 M false 66477.00 0.00 D 2024-02-03 2031-02-03 Common Stock 66477.00 0.00 D Stock Option (Right to Buy) 0.71 2026-01-21 4 M false 7605.00 0.00 D 2024-09-02 2030-09-01 Common Stock 7605.00 0.00 D Stock Option (Right to Buy) 0.64 2026-01-21 4 M false 17236.00 0.00 D 2023-10-16 2029-11-14 Common Stock 17236.00 0.00 D Stock Option (Right to Buy) 0.39 2026-01-21 4 M false 13690.00 0.00 D 2021-03-04 2028-04-26 Common Stock 13690.00 0.00 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 Plan adopted by the Reporting Person on September 24, 2025. The price reported in column 4 is an average price. These shares were sold in multiple transactions at prices ranging from $29.00 to $29.77, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/John R. Moore Attorney-in-Fact for Badreddin Edris 2026-01-21