X0407 4 2023-04-03 0 0001745999 Beam Therapeutics Inc. BEAM 0001786322 Ciaramella Giuseppe C/O BEAM THERAPEUTICS INC., 238 MAIN STREET CAMBRIDGE MA 02142 0 1 0 0 President & CSO 1 Common Stock 2023-04-03 4 S 0 1918 30.31 D 114044 D Common Stock 2023-04-04 4 S 0 1754 29.0929 D 112290 D These shares of common stock were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person prior to February 27, 2023. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $28.79 to $29.10, inclusive. The Reporting Person undertakes to provide to Beam Therapeutics Inc. ("BEAM"), any security holder of BEAM or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. By: /s/ Christine Bellon, Attorney-in-fact 2023-04-05