Convertible Preferred Stock and Stockholders' Equity (Deficit) (Tables)

12 Months Ended

Dec. 31, 2022

Stockholders' Equity Note [Abstract]

Schedule of common stock reserved for future issuance

Common stock reserved for future issuance consisted of the following:

	As of December 31,
	2022
Common stock options and restricted stock units granted and outstanding		9,387,963
Shares available for issuance under the equity incentive plans		2,409,593
Shares available for issuance under the 2021 Employee Stock Purchase Plan		706,413
Total common stock reserved for issuance		12,503,969

Summary of the Status of the Options Issued Under the Plan

A summary of the status of the options issued under the Company’s equity incentive plans as of December 31, 2022, and information with respect to the changes in options outstanding is as follows (in thousands, except share and per share data):

	Options Outstanding			Weighted Average Exercise  Price Per Share		Weighted Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value
Balance at December 31, 2021		6,591,727		$	8.04
Granted		3,112,560			9.66
Exercised		(395,050	)		1.48
Forfeited		(377,233	)		10.91
Expired		(547,014	)		5.32
Balance at December 31, 2022		8,384,990		$	9.00		8.72	$	20,499
Vested and expected to vest as of    December 31, 2022		8,384,990		$	9.00		8.72	$	20,499
Vested and exercisable at    December 31, 2022		2,219,625		$	8.06		8.31	$	5,636

Summary of the RSU under Equity incentive plan

A summary of the status of RSUs issued under the Company’s equity incentive plans as of December 31, 2022, and information with respect to the changes in RSUs outstanding is as follows:

	Service-based RSUs					Performance-based RSUs
	Units			Weighted Average Grant-Date Fair Value		Units			Weighted Average Grant-Date Fair Value
Nonvested at December 31, 2021		388,500		$	25.96		—		$	—
Granted		906,271		$	12.25		60,000		$	18.74
Vested		(278,281	)	$	11.34		(24,000	)	$	10.91
Forfeited		(49,517	)	$	16.45		—		$	—
Nonvested at December 31, 2022		966,973		$	17.81		36,000		$	3.08
Expected to vest at December 31, 2022		966,973		$	17.81		—		$	—

Schedule of Stock-based Compensation Expense for All Equity Awards

Stock-based compensation expense for all equity awards and the ESPP, has been reported in the statements of operations and comprehensive loss as follows (in thousands):

	Year Ended December 31,
	2022		2021
Research and development	$	8,123	$	2,710
General and administrative		13,571		26,321
Total	$	21,694	$	29,031

Summary of Assumptions Used in Black-Scholes Model

The fair value of each stock option granted was estimated using the Black-Scholes option pricing model. The assumptions used in the Black-Scholes option pricing model to estimate the fair value of the stock option grants issued during years ended were as follows:

	Year Ended December 31,
	2022	2021
Risk-free rate of interest	1.43%-4.15%	0.63%-1.34%
Expected term (years)	5.27 - 6.08 years	5.77 - 6.08 years
Expected stock price volatility	89.3% - 118.1%	84.2% - 90.9%
Dividend yield	0%	0%