Leases - Additional Information (Details) $ in Thousands	1 Months Ended		12 Months Ended
	Jul. 31, 2022 USD ($) ft²	May 31, 2022 USD ($) ft²	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)
Lessee, Lease, Description [Line Items]
Operating lease expense			$ 4,700	$ 1,200
Undiscounted minimum lease payments			93,175
Research and development expense on finance lease liabilities			149,555	$ 46,883
Finance lease liabilities, current			33,060
Finance lease liabilities, non-current			$ 20,871
Lonza
Lessee, Lease, Description [Line Items]
Prior notification period to terminate arrangement			12 months
Research and development expense on finance lease liabilities			$ 63,300
Finance lease liabilities, current			33,100
Finance lease liabilities, non-current			$ 20,900
Finance lease expiration date			2024-12
Lonza | Other Income, Net
Lessee, Lease, Description [Line Items]
Interest expense on finance lease liabilities			$ 1,700
Redwood, California
Lessee, Lease, Description [Line Items]
Square feet of space | ft²		51,822
Lease term		11 years 8 months 12 days
Undiscounted minimum lease payments		$ 56,500
Option to extend lease			The Redwood City lease provides for an optional five-year extension.
Option to extend lease term		5 years
Lease includes allowance for tenant improvements		$ 9,800
Operating lease, discount rate		8.50%
Rockville, Maryland
Lessee, Lease, Description [Line Items]
Square feet of space | ft²	57,902
Lease term	12 years 10 months 24 days
Undiscounted minimum lease payments	$ 31,000
Option to extend lease			The Rockville lease provides for optional two five-year extensions.
Option to extend lease term	5 years
Lease includes allowance for tenant improvements	$ 12,100
Operating lease, discount rate	12.00%
Office and Laboratory Space | Rockville, Maryland
Lessee, Lease, Description [Line Items]
Lease expiration year			2030