SCHEDULE 13G/A 0001640546 XXXXXXXX LIVE 1 Common Stock 12/31/2025 0001785530 Werewolf Therapeutics, Inc. 95075A107 200 Talcott Avenue Floor 2 Watertown MA 02472 Rule 13d-1(c) Longwood Fund III GP, LLC b DE 0 1677082 0 1677082 1677082 N 3.5 OO (1) All such shares are held of record by Longwood III (as defined in Item 2(a) below). Longwood III GP (as defined in Item 2(a) below) is the general partner of Longwood III and may be deemed to share voting and dispositive power with respect to these securities. (2) Based on 48,540,200 shares of the Issuer's Common Stock outstanding as of October 29, 2025, as reported by the Issuer's in its Form 10-Q for quarter ended September 30, 2025, filed with the United States Securities and Exchange Commission (the "SEC") on November 4, 2025 (the "Form 10-Q"). Longwood Fund III, L.P. DE 0 1677082 0 1677082 1677082 N 3.5 PN (1) All such shares are held of record by Longwood III. Longwood III GP is the general partner of Longwood III and may be deemed to share voting and dispositive power with respect to these securities. (2) Based on 48,540,200 shares of the Issuer's Common Stock outstanding as of October 29, 2025, as reported by the Issuer in the Form 10-Q. Werewolf Therapeutics, Inc. 200 Talcott Avenue, Floor 2, Watertown, MA 02472 This Amendment No. 1 (this "Amendment") amends and supplements the Schedule 13G originally filed by Longwood Fund III, L.P. ("Longwood III") and Longwood Fund III GP, LLC ("Longwood III GP" and together with Longwood III, the "Reporting Persons") with the SEC on May 14, 2021 (the "Original 13G"). This Amendment is being filed by the Reporting Persons. The address of the principal business office of each Reporting Person is 800 Boylston Street, Suite 1715, Boston, MA 02199. Longwood III GP is a limited liability company organized under the laws of the State of Delaware. Longwood III is a limited partnership organized under the laws of the State of Delaware. Y See Row 9 of the cover page for each Reporting Person and corresponding footnotes. See Row 11 of the cover page for each Reporting Person and corresponding footnotes. See Row 5 of the cover page for each Reporting Person and corresponding footnotes. See Row 6 of the cover page for each Reporting Person and corresponding footnotes. See Row 7 of the cover page for each Reporting Person and corresponding footnotes. See Row 8 of the cover page for each Reporting Person and corresponding footnotes. N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Longwood Fund III GP, LLC /s/ Robert Hadfield 02/11/2026 Longwood Fund III, L.P. /s/ Robert Hadfield 02/11/2026 *Signed pursuant to a Power of Attorney included herein as an Exhibit to this Schedule 13G.