X0407 4 2023-06-21 0 0001785530 Werewolf Therapeutics, Inc. HOWL 0001792061 DiRocco Derek C/O WEREWOLF THERAPEUTICS, INC. 200 TALCOTT AVENUE, 2ND FLOOR WATERTOWN MA 02472 1 0 0 0 0 Stock Option (right to buy) 2.81 2023-06-21 4 A 0 13200 0.00 A 2033-06-20 Common Stock 13200 13200 D The option was granted on June 21, 2023. The shares underlying the option vest in full on the earlier of the first anniversary of the grant date and the next annual meeting of stockholders following the grant date, subject to the reporting person's continued service as a director. Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the stock option for the benefit of the RA Capital Healthcare Fund, L.P. (the "Fund") and RA Capital Nexus Fund II, L.P. (the "Nexus Fund II"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received upon exercise of the stock option, which will offset advisory fees owed by the Fund and the Nexus Fund II to the Adviser. The Reporting Person therefore disclaims beneficial ownership of the stock option and underlying Common Stock. /s/ Jonathan Owen, Attorney-in-fact 2023-06-23