X0306 4 2023-01-03 0 0001785530 Werewolf Therapeutics, Inc. HOWL 0001857797 Isaacs Randi C/O WEREWOLF THERAPEUTICS, INC. 200 TALCOTT AVENUE, 2ND FLOOR WATERTOWN MA 02472 0 1 0 0 Chief Medical Officer Stock Option (right to buy) 2.05 2023-01-03 4 A 0 103300 0.00 A 2032-12-31 Common Stock 103300 103300 D The option was granted on January 3, 2023 with a Vesting Commencement Date of January 1, 2023. The shares underlying the option vest in equal monthly installments over four years, commencing on the date that is one month following the Vesting Commencement Date and vesting monthly thereafter through January 1, 2027. Exhibit Index: 24.1 Power of Attorney /s/ Jonathan Owen, Attorney-in-fact 2023-01-09